Antihyperglycemic effect of peptides of colostrum hydrolysate

Abstract

One of the promising approaches for the prevention and treatment of type 2 diabetes (T2D) is the use of biopeptides derived from proteomics data. The effect of an enzymatic hy­drolysate of cow colostrum, containing ten peptides, on the development of type 2 diabetes was studied in male Wistar rats. Three groups of Wistar rats, each consisting of seven ani­mals, were formed for the experiments: Group 1 — intact controls; T2D was induced in rats of Groups 2 and 3. Rats in Group 3 additionally received an intragastric administration of the trypsin hydrolysate of cow colostrum alongside their standard diet. In Wistar rats with in­duced T2D, the trypsin hydrolysate of cow colostrum demonstrated antihyperglycemic and antioxidant effects. Blood glucose and glycated hemoglobin levels decreased in T2D rats re­ceiving the trypsin hydrolysate compared to untreated T2D rats. Administration of the tryp­sin hydrolysate to Group 3 rats reduced body weight loss relative to Group 2 and was accom­panied by less pronounced hyperglycemia. Levels of malondialdehyde (MDA) and catalase activity decreased, while the levels of reduced glutathione and lipoprotein fractions were nor­malized.