Enhanced Therapy Using gold / cobalt ferrite nanoparticles: Synergistic Photothermal-Magnetomechanical Effect

Abstract

The study investigated the effectiveness of composite gold-cobalt ferrite nanoparticles (Au@CFO) in photothermal and magnetomechanical therapy on human hepatocarcinoma Huh7 cells. The nanoparticles demonstrated significant activity during in vitro photothermal therapy and exhibited inherent cytotoxicity, reducing cell viability by 32 % at a concentration of 100 µg/mL. Photothermal therapy using an 808 nm laser further decreased viability by 25 %, while magnetomechanical therapy in an alternating field of 100 mT reduced Huh7 cell viability by an additional 17 %. Combined photothermal and magnetomechanical therapy resulted in a 47 % reduction in hepatocarcinoma cell viability compared to the control group. However, its direct efficiency was 14 %, as confirmed by fluorescence microscopy. The results highlight the potential of Au@CFO nanoparticles for the development of combined cancer treatment strategies.